CD32B Mouse Monoclonal Antibody [A9C11] (HA601121)

UNIPROT #

P31994

PROTEIN NAME

CD32B

SYNONYMS

CD32 antibody;CD32 antigen antibody;CD32B antibody;CDw32 antibody;Fc fragment of IgG, low affinity II, receptor for (CD32) antibody;Fc fragment of IgG, low affinity IIb, receptor antibody;Fc fragment of IgG, low affinity IIb, receptor (CD32) antibody;Fc fragment of IgG, low affinity IIb, receptor for (CD32) antibody;Fc fragment of IgG, low affinity IIb, receptor for antibody;Fc gamma receptor IIB antibody;Fc gamma RII antibody;Fc gamma RIIB antibody;Fc-gamma RII antibody;Fc-gamma RII-b antibody;Fc-gamma-RIIb antibody;FCG2 antibody;FCG2B_HUMAN antibody;Fcgr2 antibody;FCGR2B antibody;FCRII antibody;FcRII-b antibody;IGFR2 antibody;IgG Fc receptor II beta antibody;IgG Fc receptor II-b antibody;Low affinity immunoglobulin gamma Fc region receptor II antibody;Low affinity immunoglobulin gamma Fc region receptor II-b antibody;Ly-17 antibody;Lym 1 antibody;Lymphocyte antigen 17 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Fc fragment of IgG receptor IIb (coded by FCGR2B gene) is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B lymphocytes. The receptor inhibits the functions of activating FcγRs, such as phagocytosis and pro-inflammatory cytokine release, mainly by clustering of FCGR2B with different activating FCGR receptors or with the BCR by immune complexes. The phosphorylated ITIM of FcγRIIB recruits the inositol phosphatases SHIP1 and SHIP2, which inhibit the Ras activation, downregulate MAPK activity and reduce PLCγ function and lead to decreased activation of PKC. Inhibition of the MAP kinase pathway, together with the anti-apoptotic kinase Akt can negatively affect proliferation and survival of the cells. FCGR2B regulates B cell activation by increasing the BCR activation threshold and suppressing B cell mediated antigen presentation to T cells through the ITIM-dependent inhibitory mechanism. Ligation of FCGR2B on B cells downregulates antibody production, prevents the membrane organization of BCR and CD19 and promotes apoptosis. Co-ligation of FCGR2B on dendritic cells inhibits maturation and blocks cell activation. .The negative regulatory role of the FCGRIIB molecule is not limited to BCR-induced B-cell activation, but is also functional on other B-cell activation pathways mediated by CD40 and IL-4. FCGR2B expression on follicular dendritic cells (FDCs) is important for capturing the antigen-containing immune complexes which are essential for the germinal centre response. FCGR2B is present on non-leukocyte cells including airway smooth muscle and liver sinusoidal endothelial cells, where small immune complexes are internalized inhibiting the pro-inflammatory signalling.