CD32A + CD32B + CD32C Recombinant Rabbit Monoclonal Antibody [JE64-17] (HA721930)

UNIPROT #

P12318

PROTEIN NAME

CD32A + CD32B + CD32C

SYNONYMS

Low affinity immunoglobulin gamma Fc region receptor II-a;Low affinity immunoglobulin gamma Fc region receptor II-b;Low affinity immunoglobulin gamma Fc region receptor II-c;IgG Fc receptor II-a;IgG Fc receptor II-b;IgG Fc receptor II-c;CDw32;Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a);Fc-gamma RII-b (Fc-gamma-RIIb; FcRII-b);Fc-gamma RII-c (Fc-gamma-RIIc; FcRII-c);CD32;FCGR2A;FCGR2B;FCGR2C;CD32, FCG2, FCGR2A1, IGFR2

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD32A: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. CD32B: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. CD32C: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.