CD28 Rabbit Polyclonal Antibody (ER2001-42)

UNIPROT #

P10747

PROTEIN NAME

CD28

SYNONYMS

CD 28 antibody;CD28 antibody;CD28 antigen antibody;CD28 molecule antibody;CD28_HUMAN antibody;MGC138290 antibody;T cell antigen CD28 antibody;T cell specific surface glycoprotein antibody;T cell specific surface glycoprotein CD28 antibody;T-cell-specific surfac

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen-presenting cells (APCs). The CD86 expression on antigen-presenting cells is constitutive (expression is independent of environmental factors). CD28 is the only B7 receptor constitutively expressed on naive T cells. Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.