CD271 Rabbit Polyclonal Antibody (1003-9)

UNIPROT #

Q9Z0W1

PROTEIN NAME

CD271

SYNONYMS

CD271 antibody;CD271 antigen antibody;Gp80 LNGFR antibody;Gp80-LNGFR antibody;Low affinity nerve growth factor receptor antibody;Low affinity neurotrophin receptor p75NTR antibody;Low-affinity nerve growth factor receptor antibody;Nerve growth factor receptor antibody;Nerve growth factor receptor TNFR superfamily member 16 antibody;NGF receptor antibody;Ngfr antibody;p75 ICD antibody;p75 Neurotrophin receptor antibody;p75 NTR antibody;p75(NTR) antibody;p75NTR antibody;TNFR Superfamily Member 16 antibody;TNFRSF16 antibody;TNR16_HUMAN antibody;Tumor necrosis factor receptor superfamily member 16 antibody

TISSUE SPECIFICITY

Detected in Schwann cells. Detected in embryonic brain, in hippocampus neurons (at protein level). Detected in brain and spinal cord.

DEVELOPMENTAL STAGE

Detected in embryonic large blood vessels at 11.5 dpc.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. O-glycosylated.; Phosphorylated on serine residues.

SUBCELLULAR LOCATION

Cell membrane, Perikaryon, Cell projection, growth cone, Cell projection, dendritic spine.

FUNCTION

NGFR p75 or CD271 is a 75kD transmembrane glycoprotein consisting of an extracellular domain which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain, and a cytoplasmic domain. NGFR p75 displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, it recognizes neurotrophins and transmits trophic signals into the cell. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system.