PRODUCT CODE: 1003-9

CD271 Rabbit Polyclonal Antibody (1003-9)

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

  • Rat

Western blot analysis on          D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.
  • Western blot analysis on          D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.
Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

CD271 Rabbit Polyclonal Antibody (1003-9)

Immunogen

Synthetic peptide corresponding to human cd271 aa 91-140 / 427 mouse.

Host

Rabbit

Positive Control

PC12, D3

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

50kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:2,000~1:5,000

TARGET

UNIPROT #

PROTEIN NAME

CD271

SYNONYMS

CD271 antibody; CD271 antigen antibody; Gp80 LNGFR antibody; Gp80-LNGFR antibody; Low affinity nerve growth factor receptor antibody; Low affinity neurotrophin receptor p75NTR antibody; Low-affinity nerve growth factor receptor antibody; Nerve growth factor receptor antibody; Nerve growth factor receptor TNFR superfamily member 16 antibody; NGF receptor antibody; Ngfr antibody; p75 ICD antibody; p75 Neurotrophin receptor antibody; p75 NTR antibody; p75(NTR) antibody; p75NTR antibody; TNFR Superfamily Member 16 antibody; TNFRSF16 antibody; TNR16_HUMAN antibody; Tumor necrosis factor receptor superfamily member 16 antibody

TISSUE SPECIFICITY

Detected in Schwann cells. Detected in embryonic brain, in hippocampus neurons (at protein level). Detected in brain and spinal cord.

DEVELOPMENTAL STAGE

Detected in embryonic large blood vessels at 11.5 dpc.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. O-glycosylated.; Phosphorylated on serine residues.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

NGFR p75 or CD271 is a 75kD transmembrane glycoprotein consisting of an extracellular domain which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain, and a cytoplasmic domain. NGFR p75 displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, it recognizes neurotrophins and transmits trophic signals into the cell. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system.