UNIPROT #

P24807

PROTEIN NAME

CD24

SYNONYMS

CD 24 antibody; CD24 antibody; CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody; CD24 antigen antibody; CD24 molecule antibody; CD24_HUMAN antibody; CD24A antibody; FLJ22950 antibody; FLJ43543 antibody; GPI linked surface mucin antibody; Heat stable antigen antibody; HSA antibody; MGC75043 antibody; Nectadrin antibody; Signal transducer CD24 antibody; Small cell lung carcinoma cluster 4 antigen antibody

SEQUENCE SIMILARITIES

Belongs to the CD24 family.

TISSUE SPECIFICITY

In lymphoid, myeloid, and erythroid cells.

POST-TRANSLATIONAL MODIFICATION

The identity of the N- and O-linked polysaccharides are not reported in PubMed:1530634. The O-linked polysaccharides on Ser-30, Ser-41, Ser-43, and Thr-51 are probably the mucin type linked to GalNAc.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

The CD24 antigen is a small heavily glycosylated, glycosylphosphatidylinositol (GPI) linked cell surface protein. It consists of a small protein core comprising 27 amino acids, which is extensively glycosylated and is bound to the membrane via a phosphatidylinositol anchor. The CD24 antigen is physiologically expressed in developing or regenerating tissue, as well as in granulocytes, keratinocytes and renal tubular epithelium. It modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor.