CD239 Recombinant Rabbit Monoclonal Antibody [JE51-07] (ET7110-04)

UNIPROT #

P50895

PROTEIN NAME

CD239

SYNONYMS

Antigen identified by monoclonal antibody F8 antibody;AU antibody;Auberger B antigen antibody;B CAM cell surface glycoprotein antibody;B cell adhesion molecule antibody;B-CAM cell surface glycoprotein antibody;Basal cell adhesion molecule (Lu and Au blood groups) antibody;Basal cell adhesion molecule (Lutheran blood group) antibody;Basal cell adhesion molecule antibody;Basal cell adhesion molecule Lu and Au blood groups antibody;Basal cell adhesion molecule Lutheran blood group antibody;Bcam antibody;BCAM_HUMAN antibody;CD239 antibody;CD239 antigen antibody;F8/G253 antigen antibody;Glycoprotein 95kDa antibody;LU antibody;Lutheran antibody;Lutheran antigen antibody;Lutheran blood group (Auberger b antigen included) antibody;Lutheran blood group Auberger b antigen included antibody;Lutheran blood group glycoprotein antibody;MSK19 antibody

TISSUE SPECIFICITY

Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

DEVELOPMENTAL STAGE

Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.

POST-TRANSLATIONAL MODIFICATION

Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239 (cluster of differentiation 239). Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. BCAM has been shown to interact with Laminin, alpha 5.