CD21 Rabbit Polyclonal Antibody (ER1706-56)

UNIPROT #

P20023

PROTEIN NAME

CD21

SYNONYMS

C3DR antibody;CD 21 antibody;CD21 antibody;Complement C3d receptor 2 antibody;Complement C3d receptor antibody;Complement component (3d/Epstein Barr virus) receptor 2 antibody;Complement receptor type 2 antibody;CR antibody;Cr2 antibody;CR2_HUMAN antibody;CVID7 antibody;EBV receptor antibody;EBV-R antibody;Epstein Barr virus receptor antibody;Epstein-Barr virus receptor antibody;EVBR antibody;SLEB9 antibody

SEQUENCE SIMILARITIES

Belongs to the receptors of complement activation (RCA) family.

TISSUE SPECIFICITY

Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD21 (also known as complement receptor (CR) type 2) is a type I integral membrane glycoprotein that serves as a receptor for the C3d complement fragment and for the Epstein-Barr virus. It plays a role in B cell activation and proliferation and undergoes phosphorylation after B cell activation with phorbol esters. CD21 is expressed on mature B cells, follicular dendritic cells, pharyngeal and cervical epithelial cells and a subset of thymocytes. The adaptive immune response is tightly regulated to limit responding cells in an antigen-specific manner. On B cells, co-receptors CD21/CD19 modulate the strength of B cell Ag receptor (BCR) signals, thereby influencing cell fate. CD21 is normally expressed during the immature and mature stages of B cell development. In association with CD19, CR21 plays an important role in enhancing mature B cell responses to foreign antigens.