CD204 Mouse Monoclonal Antibody [A8G2] (HA601090)

UNIPROT #

P21757

PROTEIN NAME

CD204

SYNONYMS

CD204 antibody;CD204 antigen antibody;CD24 antibody;Macrophage acetylated LDL receptor I and II antibody;Macrophage scavenger receptor 1 antibody;Macrophage scavenger receptor type III antibody;Macrophage scavenger receptor types I and II antibody;Msr 1 antibody;MSR1 antibody;MSRE_HUMAN antibody;phSR1 antibody;phSR2 antibody;SCARA 1 antibody;SCARA1 antibody;Scavenger receptor class A member 1 antibody;Scavenger receptor class A, member 1 antibody;Scavenger receptor type A antibody;Scvr antibody;SR A antibody;SRA antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.