Recombinant Rabbit monoclonal primary
CD20 Recombinant Rabbit Monoclonal Antibody [SY12-01] (ET1605-33)
Raji cell lysates, human tonsil tissue, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
APY antibody; ATOPY antibody; B lymphocyte antigen CD20 antibody; B Lymphocyte Cell Surface Antigen B1 antibody; B-lymphocyte antigen CD20 antibody; B-lymphocyte cell-surface antigen B1 antibody; B-lymphocyte surface antigen B1 antibody; B1 antibody; Bp 35 antibody; Bp35 antibody; CD 20 antibody; CD20 antibody; CD20 antigen antibody; CD20 receptor antibody; CD20_HUMAN antibody; CVID5 antibody; Fc epsilon receptor I beta chain antibody; Fc Fragment of IgE high affinity I receptor for beta polypeptide antibody; FCER1B antibody; High affinity immunoglobulin epsilon receptor subunit beta antibody; IgE Fc receptor subunit beta antibody; IGEL antibody; IGER antibody; IGHER antibody; LEU 16 antibody; LEU16 antibody; leukocyte surface antigen Leu 16 antibody; Leukocyte surface antigen Leu-16 antibody; Ly44 antibody; Membrane spanning 4 domains A1 antibody; Membrane spanning 4 domains subfamily A member 2 antibody; Membrane-spanning 4-domains subfamily A member 1 antibody; MS4A1 antibody; MS4A2 antibody; S7 antibody
Belongs to the MS4A family.
Expressed on B-cells.
Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
CD20 is a leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N- and C-termini. The cytoplasmic domain of CD20 contains multiple phosphorylation sites, leading to additional isoforms. CD20 is expressed primarily on B cells but has also been detected on both normal and neoplastic T cells. CD20 functions as a calcium-permeable cation channel, and it is known to accelerate the G0 to G1 progression induced by IGF-1. CD20 is activated by the IGF-1 receptor via the alpha subunits of the heterotrimeric G proteins. Activation of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loop-helix leucine zipper transcription factors.