Rabbit polyclonal primary
CD19 Rabbit Polyclonal Antibody (R1107-7)
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified
antibody; deficiency due to defect in CD19, included antibody; AW495831 antibody; B lymphocyte antigen CD19 antibody; B lymphocyte surface antigen B4 antibody; B-lymphocyte antigen CD19 antibody; B-lymphocyte surface antigen B4 antibody; B4 antibody; CD19 antibody; CD19 antigen antibody; CD19 molecule antibody; Cd19 protein antibody; CD19_HUMAN antibody; CVID3 antibody; Differentiation antigen CD19 antibody; Leu 12 antibody; Leu-12 antibody; Leu12 antibody; MGC109570 antibody; MGC12802 antibody; T-cell surface antigen Leu-12 antibody
Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level).
Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels (By similarity).
B-lymphocyte antigen CD19 also known as CD19 (Cluster of Differentiation 19), is a 95 kDa type-I transmembrane glycoprotein which is restricted to B cell antigen. On the B cell surface, CD19 associates with CD21, CD81 and Leu-13 to exert its function. CD19 is also found on the follicular dendritic cells and the early cells of myelomonocytic lineage but not on normal T cells, NK cells, monocytes, granulocytes, erythrocytes and platelets.