CD14 Rabbit Polyclonal Antibody (R1107-2)

UNIPROT #

P08571

PROTEIN NAME

CD14

SYNONYMS

CD 14 antibody;CD_antigen=CD14 antibody;CD14 antibody;CD14 antigen antibody;CD14 molecule antibody;CD14_HUMAN antibody;LPS-R antibody;Mo2 antibody;Monocyte differentiation antigen CD14 antibody;Monocyte differentiation antigen CD14 urinary form antibody;Monocyte differentiation antigen CD14, membrane-bound form antibody;Myeloid cell specific leucine rich glycoprotein antibody;Myeloid cell-specific leucine-rich glycoprotein antibody

TISSUE SPECIFICITY

Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

POST-TRANSLATIONAL MODIFICATION

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus , Secreted.

FUNCTION

CD14 is a glycophosphatidylinositol-anchored protein expressed on the surfaces of monocytes and plymorphonuclear leukocytes. It cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). CD14 acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and up-regulates cell surface molecules, including adhesion molecules.