CD137 Mouse Monoclonal Antibody [2G1] (M1701-11)

UNIPROT #

Q07011

PROTEIN NAME

CD137

SYNONYMS

4 1BB antibody;4 1BB ligand receptor antibody;4-1BB ligand receptor antibody;4-1BB Ligand Receptor T Cell antibody;4-1BB, mouse, homolog of antibody;Antigen 4-1BB Homolog antibody;CD 137 antibody;CD137 antibody;CD137 antigen antibody;CDw137 antibody;HLDA VI antibody;Homolog of mouse 4 1BB antibody;ILA antibody;induced by lymphocyte activation (ILA) antibody;Induced by lymphocyte activation antibody;Interleukin activated receptor homolog of mouse Ly63 antibody;Ly63, mouse, homolog of antibody;MGC2172 antibody;OTTHUMP00000044294 antibody;Receptor protein 4 1BB antibody;T cell antigen 4 1BB homolog antibody;T cell antigen ILA antibody;T-cell antigen 4-1BB homolog antibody;T-cell antigen ILA antibody;TNF receptor superfamily member 9 antibody;TNFRSF9 antibody;TNR9_HUMAN antibody;Tumor necrosis factor receptor superfamily member 9 antibody

TISSUE SPECIFICITY

Expressed on the surface of activated T-cells.

SUBCELLULAR LOCATION

Membrane. Extracellular space.

FUNCTION

CD137, also designated ILA and 4-1BB in mouse, belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. CD137 is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages, and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. Crosslinking of the CD137 ligand induces apoptosis in resting lymphocytes. In contrast, CD137 regulates peripheral monocyte survival by inducing a cytokine release profile, and is mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Soluble forms of CD137 are found in sera from patients with rheumatoid arthritis and may provide a negative control mechanism for immune responses.