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CD11b Mouse Monoclonal Antibody [4-6] (EM1701-42)

Price: Regular price $325.00

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Catalog# EM1701-42

Mouse Monoclonal to CD11b

Tested for

  • IHC-P

  • ICC

  • FC

React with

  • Human

Specifications

Product Type

Mouse monoclonal primary

Product Name

CD11b Mouse Monoclonal Antibody [4-6] (EM1701-42)

Immunogen

Recombinant protein within human cd11b aa 544-743 / 1,152.

Host

Mouse

Positive Control

A431, LOVO, THP-1,human tonsil tissue, human spleen tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

4-6

APPLICATION DILUTION

  • ICC

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC:1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein G affinity purified.

Molecular Weight

127 kDa

Isotype

IgG2b

TARGET

UNIPROT #

P11215

PROTEIN NAME

CD11b

SYNONYMS

antigen CD11b (p170) antibody;Antigen CD11b p170 antibody;CD11 antigen like family member B antibody;CD11 antigen-like family member B antibody;CD11b antibody;CD11b/CD18 antibody;CD49d antibody;Cell surface glycoprotein MAC-1 subunit alpha antibody;Complement component 3 receptor 3 subunit antibody;Complement Component Receptor 3 Alpha antibody;Complement receptor type 3, alpha subunit antibody;CR 3 alpha chain (CR3A) antibody;CR 3 alpha chain antibody;CR-3 alpha chain antibody;CR3 antibody;CR3A antibody;F730045J24Rik antibody;Integrin Alpha M antibody;Integrin alpha M chain antibody;Integrin alpha-M antibody;Integrin beta 2 alpha subunit antibody;Integrin subunit alpha M antibody;integrin, alpha M (complement component 3 receptor 3 subunit) antibody;ITAM_HUMAN antibody;ITGAM antibody;Leukocyte adhesion receptor MO1 antibody;Ly-40 antibody;MAC 1 antibody;Mac-1a antibody;MAC1 antibody;Mac1, alpha subunit antibody;MAC1A antibody;Macrophage antigen alpha polypeptide antibody;MGC117044 antibody;Mo1, alpha subunit antibody;MO1A antibody;Neutrophil adherence receptor alpha M subunit antibody;Neutrophil adherence receptor antibody;SLEB6 antibody

SEQUENCE SIMILARITIES

Belongs to the integrin alpha chain family.

TISSUE SPECIFICITY

Predominantly expressed in monocytes and granulocytes. Expressed in neutrophils (at protein level).

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development.

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