UNIPROT #

P20701

PROTEIN NAME

CD11a

SYNONYMS

Lymphocyte function associated antigen, type 1, alpha subunit antibody; Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody; Antigen CD11A antibody; CD 11a antibody; CD11 antigen-like family member A antibody; CD11a antibody; CD11a antigen antibody; Integrin Alpha L antibody; Integrin alpha-L antibody; Integrin gene promoter antibody; Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) antibody; ITAL_HUMAN antibody; Itgal antibody; ITGAL protein antibody; Leukocyte adhesion glycoprotein LFA 1 alpha chain antibody; Leukocyte adhesion glycoprotein LFA-1 alpha chain antibody; Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain antibody; Leukocyte function associated molecule 1 alpha chain antibody; Leukocyte function-associated molecule 1 alpha chain antibody; LFA 1 alpha (LFA1A) antibody; LFA 1 alpha antibody; LFA 1 antibody; LFA 1A antibody; LFA-1A antibody; LFA1A antibody; Ly15 antibody; Ly21 antibody; Lymphocyte function associated antigen 1 antibody; Lymphocyte Function Associated Antigen Type 1 alpha antibody; lymphocyte function-associated antigen 1, alpha polypeptide antibody; p180 antibody

SEQUENCE SIMILARITIES

Belongs to the integrin alpha chain family.

TISSUE SPECIFICITY

Leukocytes.

POST-TRANSLATIONAL MODIFICATION

In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.