PRODUCT CODE: 0902-1

CD105 Rabbit Polyclonal Antibody (0902-1)

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

Western blot analysis on D3 using anti CD105 polyclonal antibody.
  • Western blot analysis on D3 using anti CD105 polyclonal antibody.
Western blot analysis on D3 using anti CD105 polyclonal antibody.

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

CD105 Rabbit Polyclonal Antibody (0902-1)

Immunogen

Synthetic peptide within mouse cd105 aa 16-65 / 653.

Host

Rabbit

Positive Control

CD3

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

74kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500

TARGET

UNIPROT #

PROTEIN NAME

CD105

SYNONYMS

AI528660 antibody; AI662476 antibody; CD 105 antibody; CD105 antibody; CD105 antigen antibody; EGLN_HUMAN antibody; END antibody; Endoglin antibody; Eng antibody; FLJ41744 antibody; HHT1 antibody; ORW antibody; ORW1 antibody; Osler Rendu Weber syndrome 1 antibody; RP11 228B15.2 antibody; S-endoglin antibody; SN6 antibody

TISSUE SPECIFICITY

Detected on blood vessels (at protein level). Detected on adult pulmonary artery, capillaries supporting the heart muscle and lung alveolar capillary endothelial cells. Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus.

DEVELOPMENTAL STAGE

Detected in embryo (at protein level). Detected in endothelium from yolk sac vessels.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1. This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous malformations in different organs including brain, lung, and liver.