CCK4 Mouse Monoclonal Antibody [A11A9] (HA601344)

UNIPROT #

Q13308

PROTEIN NAME

CCK4

SYNONYMS

8430404F20Rik antibody;CCK 4 antibody;CCK-4 antibody;Colon carcinoma kinase 4 antibody;Human colon carcinoma kinase 4 (CCK4) mRNA complete cds antibody;Inactive tyrosine-protein kinase 7 antibody;mPTK7/CCK4 antibody;OTTHUMP00000217016 antibody;Protein tyrosine kinase PTK 7 antibody;Protein-tyrosine kinase 7 antibody;Pseudo tyrosine kinase receptor 7 antibody;PTK 7 antibody;PTK7 antibody;PTK7 protein tyrosine kinase 7 antibody;PTK7 protein tyrosine kinase antibody;PTK7_HUMAN antibody;Serum response factor antibody;Srf antibody;Tyrosine-protein kinase-like 7 antibody

SUBCELLULAR LOCATION

Membrane, Cell junction.

FUNCTION

Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene. Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene an intracellular domain with tyrosine kinase homology and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. PTK7 serves as a context-dependent signalling switch for the Wnt pathways (particularly in planar cell polarity related functions such as convergent extension and neural crest cell migration) and appears to have similar functions for plexin and Flt-1 pathways. PTK7 was identified to be highly expressed in colon cancer by Saha et al. using serial analysis of gene expression (LongSAGE).