CCDC98 Recombinant Rabbit Monoclonal Antibody [JE62-73] (HA720094)

UNIPROT #

Q6UWZ7

PROTEIN NAME

CCDC98

SYNONYMS

3830405G04Rik antibody;5630400M01Rik antibody;ABRA1 antibody;ABRAXAS antibody;Abraxas protein antibody;AI506069 antibody;AL024423 antibody;AV118690 antibody;BRCA1-A complex subunit Abraxas antibody;coiled coil domain containing 98 antibody;Coiled-coil domain-containing protein 98 antibody;F175A_HUMAN antibody;FAM175A antibody;Family with sequence similarity 175 member A antibody;FLJ11520 antibody;FLJ12642 antibody;FLJ13614 antibody;Protein FAM175A antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.