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CCDC111 Mouse Monoclonal Antibody [10-B3] (M1311-4)

Price: Regular price $350.00

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Catalog# M1311-4

Mouse Monoclonal to CCDC111

Tested for

  • IF-Cell

  • IHC-P

Reacts with

  • Human

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Specifications

Product Type

Mouse monoclonal primary

Product Name

CCDC111 Mouse Monoclonal Antibody [10-B3] (M1311-4)

Immunogen

Recombinant protein within human ccdc111 aa 1-560 / 560.

Host

Mouse

Positive Control

HepG2, human colon

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

10-B3

RRID

AB_3073070

APPLICATION DILUTION

  • IF-Cell

  • 1:100-1:200

  • IHC-P

  • 1:200

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein G affinity purified.

Molecular Weight

64kDa

Isotype

IgG1

TARGET

UNIPROT #

Q96LW4

PROTEIN NAME

CCDC111

SYNONYMS

CC111_HUMAN antibody;CCDC111 antibody;Coiled coil domain containing 111 antibody;Coiled-coil domain-containing protein 111 antibody;DNA-directed primase/polymerase protein antibody;MYP22 antibody;Primase and polymerase (DNA directed) antibody;PRIMPOL antibody

SEQUENCE SIMILARITIES

Belongs to the eukaryotic-type primase small subunit family.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. PRIMPOL shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. It is involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. PRIMPOL is required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. PRIMPOL has non-overlapping function with POLH.

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