CBR1 Rabbit Polyclonal Antibody (ER2001-45)
Catalog# ER2001-45
Rabbit Polyclonal to CBR1
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WB
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IHC-P
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Human
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Rat
Positive control:
Lane 1: SKBR-3 cell lysate
Lane 2: A549 cell lysate
Lane 3: Siha cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
CBR1 Rabbit Polyclonal Antibody (ER2001-45)
Immunogen
Synthetic peptide within human cbr1 aa 220-277.
Host
Rabbit
Positive Control
SKBR-3 cell lysate, A549 cell lysate, Siha cell lysate, rat testis tissue, human liver carcinoma tissue, human skin tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IHC-P
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1:200-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 30 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
CBR1
SYNONYMS
15 hydroxyprostaglandin dehydrogenase [NADP+] antibody;15-hydroxyprostaglandin dehydrogenase [NADP+] antibody;Carbonyl reductase [NADPH] 1 antibody;Carbonyl Reductase 1 antibody;CBR 1 antibody;CBR1 antibody;CBR1_HUMAN antibody;CRN antibody;NADPH dependent carbonyl reductase 1 antibody;NADPH-dependent carbonyl reductase 1 antibody;Prostaglandin 9 ketoreductase antibody;Prostaglandin 9-ketoreductase antibody;Prostaglandin E(2) 9 reductase antibody;Prostaglandin-E(2) 9-reductase antibody;SDR21C1 antibody
SUBCELLULAR LOCATION
Cytoplasm.
FUNCTION
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol . Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
CITATIONS
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Fenghua Zhou,et al
Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro
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IF
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Citation
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