CBL Rabbit Polyclonal Antibody (ER2001-61)

UNIPROT #

P22681

PROTEIN NAME

CBL

SYNONYMS

4732447J05Rik antibody;C CBL antibody;Cas Br M (murine) ecotropic retroviral transforming sequence antibody;Casitas B lineage lymphoma proto oncogene antibody;Casitas B-lineage lymphoma proto-oncogene antibody;CBL 2 antibody;cbl antibody;CBL_HUMAN antibody;CBL2 antibody;E3 ubiquitin protein ligase CBL antibody;E3 ubiquitin-protein ligase CBL antibody;Oncogene CBL2 antibody;Proto oncogene c CBL antibody;Proto-oncogene c-CBL antibody;RGD1561386 antibody;RING finger protein 55 antibody;RNF55 antibody;Signal transduction protein CBL antibody

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane.

FUNCTION

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome . Ubiquitinates SPRED2 . Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).