Recombinant Rabbit monoclonal primary
CBFb Recombinant Rabbit Monoclonal Antibody [JG39-35] (ET7108-87)
Recombinant protein within human cbfb aa 1-200.
Rat kidney tissue, human kidney tissue, SiHa.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CBF b antibody; CBF beta antibody; CBF-beta antibody; CBFB antibody; CBFbeta antibody; Core binding factor beta subunit antibody; core binding factor subunit beta antibody; Core-binding factor subunit beta antibody; PEA 2 antibody; PEA2 antibody; PEA2 beta antibody; PEA2-beta antibody; PEA2beta antibody; PEBB_HUMAN antibody; PEBP 2B antibody; PEBP2 beta antibody; PEBP2-beta antibody; PEBP2B antibody; PEBP2beta antibody; Polyomavirus enhancer binding protein 2 beta subunit antibody; Polyomavirus enhancer-binding protein 2 beta subunit antibody; SL3 3 enhancer factor 1 beta subunit antibody; SL3 3 enhancer factor 1 subunit beta antibody; SL3-3 enhancer factor 1 subunit beta antibody; SL3/AKV core binding factor beta subunit antibody; SL3/AKV core-binding factor beta subunit antibody
Belongs to the CBF-beta family.
The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, a and b, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2a subunits, PEBP2aA, PEBP2aB and PEBP2aC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory b subunit, which facilitates DNA binding of the a subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2b is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2b/CBFB-SMMHC, that is associated with human acute myeloid leukemia.