CBARA1 Rabbit Polyclonal Antibody (ER1803-99)
Catalog# ER1803-99
Rabbit Polyclonal to CBARA1
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WB
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Human
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Mouse
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Rat
Positive control:
Lane 1: Mouse kidney tissue lysate
Lane 2: Rat brain tissue lysate
Lane 3: Hela cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
CBARA1 Rabbit Polyclonal Antibody (ER1803-99)
Immunogen
Recombinant protein within human cbara1 aa 14-154 / 476.
Host
Rabbit
Positive Control
Mouse kidney tissue, rat brain tissue, Hela.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB:1:500-1:2,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 54 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
CBARA1
SYNONYMS
Allergen Hom s 4 antibody;ara CALC antibody;atopy related autoantigen antibody;atopy related autoantigen CALC antibody;Atopy-related autoantigen CALC antibody;CALC antibody;calcium binding atopy related autoantigen 1 antibody;Calcium uptake protein 1 antibody;calcium uptake protein 1, mitochondrial antibody;Calcium-binding atopy-related autoantigen 1 antibody;CBARA1 antibody;EFHA3 antibody;FLJ12684 antibody;MICU1 antibody;MICU1_HUMAN antibody;mitochondrial antibody;mitochondrial calcium uptake 1 antibody;MPXPS antibody
SEQUENCE SIMILARITIES
Belongs to the MICU1 family. MICU1 subfamily.
TISSUE SPECIFICITY
Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
SUBCELLULAR LOCATION
Mitochondrion.
FUNCTION
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Alternatively spliced transcript variants encoding different isoforms have been described.
CITATIONS
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Zhong, C., Yang, J., Zhang, Y., Fan, X., Fan, Y., Hua, N., Li, D., Jin, S., Li, Y., Chen, P., Chen, Y., Cai, X., Zhang, Y., Jiang, L., Yang, W., Yu, P., & Lin, H.
TRPM2 Mediates Hepatic Ischemia-Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression
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WB
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Mouse
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Citation
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