Caveolin-3 Recombinant Rabbit Monoclonal Antibody [SY22-06] (ET1607-16)

UNIPROT #

P56539

PROTEIN NAME

Caveolin-3

SYNONYMS

CAV3 antibody;CAV3_HUMAN antibody;Caveolin 3 antibody;Caveolin-3 antibody;LGMD1C antibody;LQT9 antibody;M-caveolin antibody;MGC126100 antibody;MGC126101 antibody;MGC126129 antibody;OTTHUMP00000115603 antibody;OTTHUMP00000207105 antibody;VIP 21 antibody;VIP21 antibody

SEQUENCE SIMILARITIES

Belongs to the caveolin family.

TISSUE SPECIFICITY

Expressed predominantly in muscle.

POST-TRANSLATIONAL MODIFICATION

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.

SUBCELLULAR LOCATION

Golgi apparatus membrane, Cell membrane, Membrane.

FUNCTION

Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated alpha and beta, share a distinct but overlapping cellular distribution and differ by an amino terminal 31 amino acid sequence which is absent from the beta isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms.