Lane 1: A549 cell lysate
Lane 2: MCF-7 cell lysate
Lane 3: SK-Br-3 cell lysate
Recombinant Rabbit monoclonal primary
Cathepsin D Recombinant Rabbit Monoclonal Antibody [SU0360] (ET1608-49)
Synthetic peptide within c-terminal human cathepsin d.
A549 cell lysate, MCF-7 cell lysate, SK-Br-3 cell lysate, PANC-1, AGS, human lung tissue, human liver tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human pancreas tissue, mouse prostate tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
CatD antibody; CATD_HUMAN antibody; Cathepsin D antibody; Cathepsin D heavy chain antibody; CD antibody; Ceroid lipofuscinosis neuronal 10 antibody; CLN10 antibody; CPSD antibody; ctsd antibody; Epididymis secretory sperm binding protein Li 130P antibody; HEL S 130P antibody; Lysosomal aspartyl peptidase antibody; Lysosomal aspartyl protease antibody; MGC2311 antibody
Belongs to the peptidase A1 family.
Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level).
N- and O-glycosylated.; Undergoes proteolytic cleavage and activation by ADAM30.; As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified. An additional form starting at Ala-168 has also been identified.
Extracellular space, Lysosome, Melanosome.
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsins may also cleave some protein precursors, thereby releasing regulatory peptides. The promoter region of the cathepsin D gene contains five Sp1 binding sites and four AP-2 binding sites.