Cathepsin C Recombinant Rabbit Monoclonal Antibody [PSH19-36] (HA724068)

UNIPROT #

P53634

PROTEIN NAME

Cathepsin C

SYNONYMS

AI047818 antibody;CATC antibody;CATC_HUMAN antibody;Cathepsin C antibody;Cathepsin J antibody;CPPI antibody;CTSC antibody;Dipeptidyl peptidase 1 antibody;Dipeptidyl peptidase 1 light chain antibody;Dipeptidyl peptidase I antibody;Dipeptidyl peptidase I exclusion domain chain antibody;Dipeptidyl peptidase I heavy chain antibody;Dipeptidyl peptidase I light chain antibody;Dipeptidyl transferase antibody;DPP I antibody;DPP-I antibody;DPPI antibody;EC 3.4.14.1 antibody;HMS antibody;JP antibody;JPD antibody;MGC126959 antibody;PALS antibody;PDON1 antibody;PLS antibody

SUBCELLULAR LOCATION

Lysosome.

FUNCTION

Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I or DPP1) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. In humans, it is encoded by the CTSC gene. Cathepsin C appears to be a central coordinator for activation of many serine proteases in immune/inflammatory cells. Cathepsin C catalyses excision of dipeptides from the N-terminus of protein and peptide substrates, except if (i) the amino group of the N-terminus is blocked, (ii) the site of cleavage is on either side of a proline residue, (iii) the N-terminal residue is lysine or arginine, or (iv) the structure of the peptide or protein prevents further digestion from the N-terminus.