Cathepsin B Rabbit Polyclonal Antibody (R1407-1)

UNIPROT #

P07858

PROTEIN NAME

Cathepsin B

SYNONYMS

Amyloid precursor protein secretase antibody;APP secretase antibody;APPS antibody;CATB_HUMAN antibody;Cathepsin B heavy chain antibody;Cathepsin B1 antibody;CathepsinB antibody;CPSB antibody;CTSB antibody;cysteine protease antibody;OTTHUMP00000116009 antibody;OTTHUMP00000229510 antibody;OTTHUMP00000229511 antibody;OTTHUMP00000229512 antibody;OTTHUMP00000229514 antibody;OTTHUMP00000229515 antibody;OTTHUMP00000229516 antibody;Preprocathepsin B antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C1 family.

TISSUE SPECIFICITY

Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.

SUBCELLULAR LOCATION

Secreted

FUNCTION

Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis. In humans, cathepsin B is encoded by the CTSB gene. Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions. Cathepsin B may enhance the activity of other proteases, including matrix metalloproteinase, urokinase (serine protease urokinase plasminogen activator), and cathepsin D, and thus it has an essential position for the proteolysis of extracellular matrix components, intercellular communication disruption, and reduced protease inhibitor expression. It is also involved in autophagy and catabolism, which is advantageous in tumor malignancy, and it is possibly involved in specific immune resistance. Additionally, it was recently determined to have minor ligase activity with the ability to attach peptide fragments via an amide bond.