Lane 1: C2C12 cell lysate
Lane 2: Hela cell lysate
Recombinant Rabbit monoclonal primary
Caspase-9 Recombinant Rabbit Monoclonal Antibody [SZ29-01] (ET1603-27)
C2C12 cell lysate, Hela cell lysate, Hela, HepG2, A549, human tonsil tissue, mouse spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
APAF-3 antibody; APAF3 antibody; Apoptosis related cysteine peptidase antibody; Apoptotic protease Mch-6 antibody; Apoptotic protease-activating factor 3 antibody; CASP-9 antibody; CASP9 antibody; CASP9_HUMAN antibody; Caspase 9 apoptosis related cysteine peptidase antibody; Caspase 9 Dominant Negative antibody; Caspase 9c antibody; Caspase-9 antibody; Caspase-9 subunit p10 antibody; ICE LAP6 antibody; ICE like apoptotic protease 6 antibody; ICE-LAP6 antibody; ICE-like apoptotic protease 6 antibody; MCH6 antibody; PPP1R56 antibody; protein phosphatase 1, regulatory subunit 56 antibody; RNCASP9 antibody
Belongs to the peptidase C14A family.
Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Expressed at low levels in fetal heart, at moderate levels in neonate heart, and at high levels in adult heart.
Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.; Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
Liu, Junjun et al.
Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis. | Life Sciences 
Chen, Qiuhua et al.
Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway. | Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie