PRODUCT CODE: ET1611-83

Caspase-6 p18 Recombinant Rabbit Monoclonal Antibody [SN07-26] (ET1611-83)

  • Recombinant

Applications

  • WB

  • IP

REACTIVITY

  • Human

Western blot analysis of Caspase-6 p18 on U937 cells lysates using anti-Caspase-6 p18 antibody at 1/1,000 dilution.
  • Western blot analysis of Caspase-6 p18 on U937 cells lysates using anti-Caspase-6 p18 antibody at 1/1,000 dilution.
Western blot analysis of Caspase-6 p18 on U937 cells lysates using anti-Caspase-6 p18 antibody at 1/1,000 dilution.

Applications

  • WB

  • IP

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Caspase-6 p18 Recombinant Rabbit Monoclonal Antibody [SN07-26] (ET1611-83)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

U937.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SN07-26

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

18/33 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

TARGET

UNIPROT #

PROTEIN NAME

Caspase-6 p18

SYNONYMS

Apoptotic protease Mch-2 antibody; Apoptotic protease MCH2 antibody; CASP-6 antibody; CASP6 antibody; CASP6_HUMAN antibody; Caspase 6 antibody; Caspase 6 apoptosis related cysteine protease antibody; Caspase 6, apoptosis related cysteine peptidase antibody; Caspase-6 subunit p11 antibody; Caspase-6 subunit p20 antibody; Mch2 antibody; OTTHUMP00000162742 antibody; OTTHUMP00000162743 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C14A family.

POST-TRANSLATIONAL MODIFICATION

Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.