CASK Rabbit Polyclonal Antibody (ER1803-62)

UNIPROT #

O14936

PROTEIN NAME

CASK

SYNONYMS

CAGH39 antibody;Caki antibody;Calcium/calmodulin dependent serine protein kinase antibody;Calcium/calmodulin dependent serine protein kinase (MAGUK family) antibody;Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase antibody;Calcium/calmodulin-dependent serine protein kinase antibody;CAMGUK antibody;CAMGUK protein antibody;CAMGUK, drosophila, homolog of antibody;casK antibody;CMG antibody;CSKP_HUMAN antibody;DXPri1 antibody;DXRib1 antibody;FGS4 antibody;FLJ22219 antibody;FLJ31914 antibody;hCASK antibody;LIN 2 antibody;Lin 2 homolog antibody;LIN2 antibody;Lin2 homolog antibody;MICPCH antibody;MRXSNA antibody;Pals3 antibody;Peripheral plasma membrane protein CASK antibody;Protein lin-2 homolog antibody;TNRC8 antibody;Trinucleotide repeat containing 8 antibody;Vertebtate LIN2 homolog antibody

SEQUENCE SIMILARITIES

In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.; Belongs to the MAGUK family.

TISSUE SPECIFICITY

Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.

SUBCELLULAR LOCATION

Plasma membrane. Nucleus.

FUNCTION

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.