CAMK2D Rabbit Polyclonal Antibody (R1305-2)

UNIPROT #

Q13557

PROTEIN NAME

CAMK2D

SYNONYMS

Calcium / calmodulin dependent protein kinase 2 delta antibody;Calcium / calmodulin dependent protein kinase II delta antibody;calcium/calmodulin-dependent protein kinase (CaM kinase) II delta antibody;calcium/calmodulin-dependent protein kinase type II delta chain antibody;Calcium/calmodulin-dependent protein kinase type II subunit delta antibody;CAM kinase 2 delta antibody;CAM kinase II delta antibody;CaM kinase II delta subunit antibody;CaM kinase II subunit delta antibody;CaM-kinase II delta chain antibody;CAMK 2d antibody;CaMK-II delta subunit antibody;CaMK-II subunit delta antibody;CAMK2D antibody;CAMKD antibody;CAMKI antibody;KCC2D_HUMAN antibody;RATCAMKI antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

TISSUE SPECIFICITY

Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.