Calreticulin Recombinant Rabbit Monoclonal Antibody [SU37-03] (ET1608-60)

UNIPROT #

P27797

PROTEIN NAME

Calreticulin

SYNONYMS

Autoantigen RO antibody;CALR antibody;CALR protein antibody;CALR_HUMAN antibody;Calregulin antibody;Calreticulin antibody;cC1qR antibody;CRP55 antibody;CRT antibody;CRTC antibody;Endoplasmic reticulum resident protein 60 antibody;Epididymis secretory sperm binding protein Li 99n antibody;ERp60 antibody;FLJ26680 antibody;grp60 antibody;HACBP antibody;HEL S 99n antibody;RO antibody;Sicca syndrome antigen A (autoantigen Ro; calreticulin) antibody;Sicca syndrome antigen A antibody;SSA antibody

SEQUENCE SIMILARITIES

Belongs to the calreticulin family.

SUBCELLULAR LOCATION

Endoplasmic reticulum lumen, Cytoplasm, Secreted, Cell surface, Sarcoplasmic reticulum lumen, nucleus.

FUNCTION

Calnexin and calregulin (also called calreticulin) are calcium-binding proteins that are localized to the endoplasmic reticulum, Calnexin to the membrane and calregulin to the lumen. Calnexin is a type I membrane protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a role in assisting with protein assembly and in retaining unassembled protein subunits in the endoplasmic reticulum. Calregulin has both low- and high-affinity calcium-binding sites. Neither Calnexin nor calregulin contains the calcium-binding "E-F hand" motif found in calmodulins. Calnexin and calregulin are important for the maturation of glycoproteins in the endoplasmic reticulum and appear to bind many of the same proteins.