Calreticulin Mouse Monoclonal Antibody [7B2] (EM1701-61)

UNIPROT #

P27797

PROTEIN NAME

Calreticulin

SYNONYMS

Autoantigen RO antibody;CALR antibody;CALR protein antibody;CALR_HUMAN antibody;Calregulin antibody;Calreticulin antibody;cC1qR antibody;CRP55 antibody;CRT antibody;CRTC antibody;Endoplasmic reticulum resident protein 60 antibody;Epididymis secretory sperm binding protein Li 99n antibody;ERp60 antibody;FLJ26680 antibody;grp60 antibody;HACBP antibody;HEL S 99n antibody;RO antibody;Sicca syndrome antigen A (autoantigen Ro; calreticulin) antibody;Sicca syndrome antigen A antibody;SSA antibody

SEQUENCE SIMILARITIES

Belongs to the calreticulin family.

SUBCELLULAR LOCATION

Endoplasmic reticulum. Secreted. Cytosol.

FUNCTION

Calnexin and calregulin (also called calreticulin) are calcium-binding proteins that are localized to the endoplasmic reticulum, Calnexin to the membrane and calregulin to the lumen. Calnexin is a type I membrane protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a role in assisting with protein assembly and in retaining unassembled protein subunits in the endoplasmic reticulum. Calregulin has both low- and high-affinity calcium-binding sites. Neither Calnexin nor calregulin contains the calcium-binding "E-F hand" motif found in calmodulins. Calnexin and calregulin are important for the maturation of glycoproteins in the endoplasmic reticulum and appear to bind many of the same proteins.