Calmodulin Recombinant Rabbit Monoclonal Antibody [SJ16-09] (ET1606-46)

UNIPROT #

P0DP23

PROTEIN NAME

Calmodulin

SYNONYMS

CALM 1 antibody;CALM 2 antibody;CALM 3 antibody;CALM antibody;CALM_HUMAN antibody;CALM1 antibody;CALM2 antibody;Calm3 antibody;CALML2 antibody;calmodulin 1 (phosphorylase kinase, delta) antibody;Calmodulin 2 (phosphorylase kinase, delta) antibody;Calmodulin 3 (phosphorylase kinase, delta) antibody;Calmodulin antibody;CaM antibody;CAM I antibody;CAM1 antibody;CAM2 antibody;CAM3 antibody;CAMB antibody;CAMC antibody;CAMI antibody;CAMII antibody;CPVT4 antibody;DD132 antibody;FLJ99410 antibody;LP7057 protein antibody;PHKD antibody;PHKD2 antibody;PHKD3 antibody;phosphorylase kinase delta antibody;phosphorylase kinase, delta subunit antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. CaM directly modulates the activity of protein kinases and phosphatases, ion channels and nitric oxide synthetases. It is generally involved in such diverse processes as cell proliferation, endocytosis, cellular adhesion, protein turn over and smooth muscle contraction. CaM (calmodulin) is an acidic protein, 148 amino acids in length, with four helix-loop-helix calcium binding domains. In humans, 3 distinct genes have been identified (CALM1, CALM2 and CALM3); each encoding the identical protein. CALML3 (calmodulin-like 3, or calmodulin-related protein NB-1) shares significant sequence identity with CaM and it is suggested that it may competitively bind CaM substrates. Interestingly, CaM has been shown to associate with the carboxy terminus of the dystrophin gene product, implying that it may regulate its activity.