UNIPROT #

Q9HCU4

PROTEIN NAME

Cadherin EGF LAG seven-pass G-type receptor 2

SYNONYMS

Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog antibody; Cadherin EGF LAG seven-pass G-type receptor 2 antibody; Cadherin family member 10 antibody; CDHF10 antibody; CELR2_HUMAN antibody; Celsr2 antibody; EGF like domain multiple 2 antibody; EGF-like protein 2 antibody; EGFL2 antibody; epidermal growth factor like 2 antibody; Epidermal growth factor-like protein 2 antibody; Flamingo homolog 3 antibody; Flamingo1 antibody; KIAA0279 antibody; MEGF3 antibody; Multiple EGF-like domains protein 3 antibody; Multiple epidermal growth factor-like domains 3 antibody; Multiple epidermal growth factor-like domains protein 3 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

TISSUE SPECIFICITY

Highest expression in brain and testis.

POST-TRANSLATIONAL MODIFICATION

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

Cadherin EGF LAG seven-pass G-type receptor 2 belongs to the G-protein coupled receptor 2 family, highest expressed in brain and testis. The protein encoded by the gene CELSR2 is a member of the flamingo subfamily, part of the cadherin superfamily. It may have an important role in cell/cell signaling during nervous system formation.