Applications
-
WB
-
ICC
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
Cadherin EGF LAG seven-pass G-type receptor 2 Rabbit Polyclonal Antibody (0905-6)
Immunogen
Synthetic peptide within human cadherin egf lag seven-pass g-type receptor 2 aa 21-70 / 2,923.
Host
Rabbit
Positive Control
Recombinant protein D3 (Murine Embryonic Stem Cell Line)
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Immunogen affinity purified
MOLECULAR WEIGHT
48kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:250-1:500
-
ICC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
Cadherin EGF LAG seven-pass G-type receptor 2
SYNONYMS
Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog antibody; Cadherin EGF LAG seven-pass G-type receptor 2 antibody; Cadherin family member 10 antibody; CDHF10 antibody; CELR2_HUMAN antibody; Celsr2 antibody; EGF like domain multiple 2 antibody; EGF-like protein 2 antibody; EGFL2 antibody; epidermal growth factor like 2 antibody; Epidermal growth factor-like protein 2 antibody; Flamingo homolog 3 antibody; Flamingo1 antibody; KIAA0279 antibody; MEGF3 antibody; Multiple EGF-like domains protein 3 antibody; Multiple epidermal growth factor-like domains 3 antibody; Multiple epidermal growth factor-like domains protein 3 antibody
SEQUENCE SIMILARITIES
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
TISSUE SPECIFICITY
Highest expression in brain and testis.
POST-TRANSLATIONAL MODIFICATION
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
SUBCELLULAR LOCATION
Cell membrane
FUNCTION
Cadherin EGF LAG seven-pass G-type receptor 2 belongs to the G-protein coupled receptor 2 family, highest expressed in brain and testis. The protein encoded by the gene CELSR2 is a member of the flamingo subfamily, part of the cadherin superfamily. It may have an important role in cell/cell signaling during nervous system formation.