c-Kit Recombinant Rabbit Monoclonal Antibody [PSH17-96] (HA723961)

UNIPROT #

P05532

PROTEIN NAME

c-Kit

SYNONYMS

C Kit antibody;c-Kit antibody;c-Kit Ligand antibody;CD117 antibody;Kit antibody;Kit Ligand antibody;KIT oncogene antibody;KIT proto oncogene receptor tyrosine kinase antibody;Mast cell growth factor receptor antibody;Mast/stem cell growth factor receptor Kit antibody;MGF antibody;p145 c-kit antibody;PBT antibody;Piebald trait protein antibody;Proto oncogene c Kit antibody;Proto oncogene tyrosine protein kinase Kit antibody;Proto-oncogene c-Kit antibody;SCF Receptor antibody;SCFR antibody;soluble KIT variant 1 antibody;Steel Factor Receptor antibody;Stem cell factor receptor antibody;tyrosine protein kinase Kit antibody;Tyrosine-protein kinase Kit antibody;v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog antibody;v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein antibody;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor, also known as "steel factor" or "c-kit ligand". When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. After activation, the receptor is ubiquitinated to mark it for transport to a lysosome and eventual destruction. Signaling through KIT plays a role in cell survival, proliferation, and differentiation. For instance, KIT signaling is required for melanocyte survival, and it is also involved in haematopoiesis and gametogenesis.