c-Fos Recombinant Antibody [PSH05-77] - Guinea pig IgG2 (Chimeric) (HA601374)

UNIPROT #

P01100

PROTEIN NAME

c-Fos

SYNONYMS

Activator protein 1 antibody;AP 1 antibody;C FOS antibody;Cellular oncogene c fos antibody;Cellular oncogene fos antibody;FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody;FBJ murine osteosarcoma viral oncogene homolog antibody;FBJ murine osteosarcoma viral v fos oncogene homolog antibody;FBJ Osteosarcoma Virus antibody;FOS antibody;FOS protein antibody;FOS_HUMAN antibody;G0 G1 switch regulatory protein 7 antibody;G0/G1 switch regulatory protein 7 antibody;G0S7 antibody;Oncogene FOS antibody;p55 antibody;proto oncogene c Fos antibody;Proto oncogene protein c fos antibody;Proto-oncogene c-Fos antibody;v fos FBJ murine osteosarcoma viral oncogene homolog antibody

SUBCELLULAR LOCATION

Nucleus, Endoplasmic reticulum, Cytoplasm, cytosol.

FUNCTION

Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus). It is a part of a bigger Fos family of transcription factors which includes c-Fos, FosB, Fra-1 and Fra-2. It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers.