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BTNL8 Rabbit Polyclonal Antibody (HA500240)

Price: Regular price $315.00

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Catalog# HA500240

Rabbit Polyclonal to BTNL8

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

BTNL8 Rabbit Polyclonal Antibody (HA500240)

Immunogen

Synthetic peptide within human btnl8 aa 480-500.

Host

Rabbit

Positive Control

Rat brain tissue lysate, mouse testis tissue lysate, human stomach tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071336

APPLICATION DILUTION

  • WB

  • 1:500

  • IHC-P

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 57 kDa.

Isotype

IgG

TARGET

UNIPROT #

Q6UX41

PROTEIN NAME

BTNL8

SYNONYMS

Butyrophilin-like protein 8;BTNL8;UNQ702/PRO1347

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Human BTNL8 is a 500 amino acid (aa) type I transmembrane glycoprotein that contains a signal peptide followed by an extracellular domain (ECD), a transmembrane region and a short cytoplasmic domain. The ECD of human BTNL8 shares 88% sequence identity with the ECD of mouse BTNL8. BTNL8 has two alternatively spliced forms: B7-like and BTN-like. Both isoforms of BTNL8 are expressed in a range of human tissues. The complete immunological function of BTNL molecules is only beginning to emerge. BTNL8 has been shown to be important in initiation of primary immune responses, suggesting a role in priming of naïve T lymphocytes. Down-regulation of BNTL8 mRNA levels has been associated with ulcerative colitis and colon cancer. BTNL8 are expressed in colon, lung, testis and neutrophils, and its expression is significantly decreased in ulcerative colitis, colonic tumors as compared to unaffected tissue

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