Recombinant Rabbit monoclonal primary
BRG1 Recombinant Rabbit Monoclonal Antibody [SN20-03] (ET1611-85)
HepG2 cell lysates, Hela, HepG2, SW480, RH-35, human tonsil tissue, human kidney tissue, human breast carcinoma tissue, mouse testis tissue, mouse colon tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
ATP dependent helicase SMARCA4 antibody; ATP-dependent helicase SMARCA4 antibody; BAF 190 antibody; BAF190 antibody; BAF190A antibody; Brahma protein like 1 antibody; BRG1 antibody; BRG1 associated factor 190A antibody; BRG1 protein antibody; BRG1-associated factor 190A antibody; BRM/SWI2 related gene 1 antibody; Global transcription activator homologous sequence antibody; global transcription activator snf2l4 antibody; Homeotic gene regulator antibody; hSNF2b antibody; Mitotic growth and transcription activator antibody; MRD16 antibody; Nuclear protein GRB1 antibody; Protein brahma homolog 1 antibody; Protein BRG-1 antibody; Protein BRG1 antibody; RTPS2 antibody; SMARC A4 antibody; SMARCA4 antibody; SMCA4_HUMAN antibody; SNF2 antibody; SNF2 beta antibody; SNF2 like 4 antibody; SNF2-beta antibody; SNF2B antibody; SNF2L4 antibody; SNF2LB antibody; Sucrose nonfermenting like 4 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 antibody; SWI2 antibody; Transcription activator BRG1 antibody
Belongs to the SNF2/RAD54 helicase family.
Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level).
The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2α) and Brg-1 (also designated SNF2β) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).