BNC1 Rabbit Polyclonal Antibody (R1309-6)

UNIPROT #

Q01954

PROTEIN NAME

BNC1

SYNONYMS

AI047752 antibody;AW546376 antibody;basonuclin 1 antibody;BNC antibody;Bnc1 antibody;BNC1_HUMAN antibody;BSN1 antibody;HsT19447 antibody;zinc finger protein basonuclin antibody;Zinc finger protein basonuclin-1 antibody

TISSUE SPECIFICITY

In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level). In hair follicles, mainly expressed in the outer root sheath (at protein level). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart. Expressed in the ovary, notably in oocytes.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.

SUBCELLULAR LOCATION

Cytoplasm, nucleus

FUNCTION

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene. The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.