BMPR1B Rabbit Polyclonal Antibody (R1311-4)

UNIPROT #

O00238

PROTEIN NAME

BMPR1B

SYNONYMS

Activin receptor like kinase 6 antibody;Acvrlk6 antibody;ALK 6 antibody;ALK6 antibody;alk6tr antibody;BMP type-1B receptor antibody;BMPR IB antibody;BMPR-1B antibody;Bmpr1b antibody;BMPRIB antibody;BMR1B_HUMAN antibody;Bone morphogenetic protein receptor type 1B antibody;Bone morphogenetic protein receptor type IB antibody;Bone morphogenetic protein receptor type-1B antibody;BR 1b antibody;BR1b antibody;CDw 293 antibody;CDw293 antibody;CDw293 antigen antibody;CFK 43a antibody;CFK43a antibody;Serine/threonine receptor kinase antibody;zALK 6 antibody;zALK6 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

BMPR1B is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. The BMPR1B receptor plays a role in the formation of middle and proximal phalanges. Mutations in this gene have been associated with primary pulmonary hypertension. In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations.