Rabbit polyclonal primary
BMPR1A Rabbit Polyclonal Antibody (R1510-1)
Hela, HepG2, SKOV-3, human liver carcinoma tissue, human kidney tissue, mouse skeletal muscle tissue, mouse smooth muscle tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
10q23del antibody; Activin A receptor type II like kinase 3 antibody; Activin receptor like kinase 3 antibody; Activin receptor-like kinase 3 antibody; ACVRLK 3 antibody; ACVRLK3 antibody; ALK 3 antibody; ALK-3 antibody; ALK3 antibody; BMP type-1A receptor antibody; BMPR 1A antibody; Bmpr antibody; BMPR-1A antibody; Bmpr1a antibody; BMR1A_HUMAN antibody; Bone morphogenetic protein receptor type IA antibody; Bone morphogenetic protein receptor type IA precursor antibody; Bone morphogenetic protein receptor type-1A antibody; BR 1a antibody; BR1a antibody; CD 292 antibody; CD292 antibody; CD292 antigen antibody; EC 126.96.36.199 antibody; Serine threonine protein kinase receptor R5 antibody; Serine threonine protein kinase receptor R5 precursor antibody; Serine/threonine-protein kinase receptor R5 antibody; SKR 5 antibody; SKR5 antibody; zBMPR IA antibody; zBMPRIA antibody
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Highly expressed in skeletal muscle.
Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Two type I receptors have been characterized, BMPR-IA (also designated SKR5, ALK-3, and BRK-1) and BMPR-IB (also designated ALK-6 and SKR 6), that bind to bone morphogenetic proteins (BMP)-2, BMP-4, and osteogenic protein (OP)-1 (also designated BMP-7). BMPR-IA and BMPR-IB are both expressed in human glioma cell lines. The type II receptor, BMPR-II, efficiently binds to OP-1 and BMP-2 and weakly binds BMP-4, and it is widely expressed in different tissues, including brain. The BMP receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morphogenesis in a dose dependent fashion.