PRODUCT CODE: R1510-1

BMPR1A Rabbit Polyclonal Antibody (R1510-1)

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

  • Rat

Western blot analysis on 293 cell lysates using anti-BMPR1A rabbit polyclonal antibody.
  • Western blot analysis on 293 cell lysates using anti-BMPR1A rabbit polyclonal antibody.
  • Immunocytochemical staining of Hela cells using anti-BMPR1A rabbit polyclonal antibody.
  • Immunocytochemical staining of HepG2 cells using anti-BMPR1A rabbit polyclonal antibody.
  • Immunocytochemical staining of SKOV-3 cells using anti-BMPR1A rabbit polyclonal antibody.
  • Immunohistochemical analysis of paraffin- embedded human liver carcinoma tissue using anti-BMPR1A rabbit polyclonal antibody.
  • Immunohistochemical analysis of paraffin- embedded human liver carcinoma tissue using anti-BMPR1A rabbit polyclonal antibody.
  • Immunohistochemical analysis of paraffin- embedded human kidney tissue using anti-BMPR1A rabbit polyclonal antibody.
  • Immunohistochemical analysis of paraffin- embedded mouse skeletal muscle tissue using anti-BMPR1A rabbit polyclonal antibody.
  • Immunohistochemical analysis of paraffin- embedded mouse smooth muscle tissue using anti-BMPR1A rabbit polyclonal antibody.
  • Immunohistochemical analysis of paraffin- embedded mouse kidney tissue using anti-BMPR1A rabbit polyclonal antibody.
  • Flow cytometric analysis of Jurkat cells with BMPR1A antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti mouse IgG was used as the secondary antibody.
Western blot analysis on 293 cell lysates using anti-BMPR1A rabbit polyclonal antibody.

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

BMPR1A Rabbit Polyclonal Antibody (R1510-1)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Hela, HepG2, SKOV-3, human liver carcinoma tissue, human kidney tissue, mouse skeletal muscle tissue, mouse smooth muscle tissue, mouse kidney tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Peptide affinity purified

MOLECULAR WEIGHT

60kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,1000

  • ICC

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

TARGET

UNIPROT #

PROTEIN NAME

BMPR1A

SYNONYMS

10q23del antibody; Activin A receptor type II like kinase 3 antibody; Activin receptor like kinase 3 antibody; Activin receptor-like kinase 3 antibody; ACVRLK 3 antibody; ACVRLK3 antibody; ALK 3 antibody; ALK-3 antibody; ALK3 antibody; BMP type-1A receptor antibody; BMPR 1A antibody; Bmpr antibody; BMPR-1A antibody; Bmpr1a antibody; BMR1A_HUMAN antibody; Bone morphogenetic protein receptor type IA antibody; Bone morphogenetic protein receptor type IA precursor antibody; Bone morphogenetic protein receptor type-1A antibody; BR 1a antibody; BR1a antibody; CD 292 antibody; CD292 antibody; CD292 antigen antibody; EC 2.7.11.30 antibody; Serine threonine protein kinase receptor R5 antibody; Serine threonine protein kinase receptor R5 precursor antibody; Serine/threonine-protein kinase receptor R5 antibody; SKR 5 antibody; SKR5 antibody; zBMPR IA antibody; zBMPRIA antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

TISSUE SPECIFICITY

Highly expressed in skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Membrane

FUNCTION

Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Two type I receptors have been characterized, BMPR-IA (also designated SKR5, ALK-3, and BRK-1) and BMPR-IB (also designated ALK-6 and SKR 6), that bind to bone morphogenetic proteins (BMP)-2, BMP-4, and osteogenic protein (OP)-1 (also designated BMP-7). BMPR-IA and BMPR-IB are both expressed in human glioma cell lines. The type II receptor, BMPR-II, efficiently binds to OP-1 and BMP-2 and weakly binds BMP-4, and it is widely expressed in different tissues, including brain. The BMP receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morphogenesis in a dose dependent fashion.