BLOS1 Rabbit Polyclonal Antibody (ER1901-35)

UNIPROT #

O22929

PROTEIN NAME

BLOS1

SYNONYMS

Biogenesis of lysosome-related organelles complex 1 subunit 1 antibody;BL1S1_HUMAN antibody;BLOC-1 subunit 1 antibody;Bloc1s1 antibody;BLOS1 antibody;GCN5-like protein 1 antibody;GCN5L1 antibody;Protein RT14 antibody;RT14 antibody

SUBCELLULAR LOCATION

Endosome, cytoplasm.

FUNCTION

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that mediates the vacuolar degradative transport via the intracellular vesicle trafficking from the endosome to the vacuole. Probably regulates the PIN1 and PIN2 homeostasis through its interaction with SNX1. An eight-subunit protein complex, BLOC-1, which is involved in endosomal transport from the endosomes to the lysosomes, has been identified in both human and mice. In this study, two homologous subunits of this complex, BLOS1 (or AtGCN5L1) and BLOS2, have been characterized in Arabidopsis. Both BLOS1 and BLOS2 interacted with SNX1 on the sorting endosomes. Inducible RNAi lines with reduced levels of BLOS1 had longer primary roots and more lateral roots. Consistently, PIN1 and PIN2 were increased in BLOS1 RNAi lines, implicating an impaired transport from the endosomes to the vacuoles. These results suggest that a putative BLOC-1 complex in Arabidopsis might mediate the vacuolar degradative transport through direct interaction with SNX1 to regulate the homeostasis of PIN1 and PIN2, which is important for plant growth and development.