Biotin Conjugated Human VE Cadherin Recombinant Rabbit Monoclonal Antibody [PSH02-62] (HA722635B)

UNIPROT #

P33151

PROTEIN NAME

Human VE Cadherin

SYNONYMS

7B 4 antibody;7B4 antibody;7B4 antigen antibody;CADH5_HUMAN antibody;Cadherin 5 antibody;Cadherin 5 type 2 antibody;Cadherin 5, type 2 (vascular endothelium) antibody;Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody;cadherin, vascular endothelial antibody;cadherin, vascular endothelial, 1 antibody;Cadherin-5 antibody;Cadherin5 antibody;CD 144 antibody;CD144 antibody;CD144 antigen antibody;CDH 5 antibody;CDH5 antibody;CDH5 protein antibody;Endothelial specific cadherin antibody;FLJ17376 antibody;OTTHUMP00000174777 antibody;Vascular endothelial cadherin antibody;Vascular epithelium cadherin antibody;VE Cad antibody;VE-cadherin antibody;VEC antibody

SUBCELLULAR LOCATION

Cell junction. Cell membrane. Membrane.

FUNCTION

VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.