Biotin Conjugated Human TNF-beta Recombinant Rabbit Monoclonal Antibody [PS01-19] (HA722651B)

UNIPROT #

P01374

PROTEIN NAME

Human TNF-beta

SYNONYMS

LTalpha antibody;DAMA-25N12.13-004 antibody;DIF antibody;LT alpha antibody;LT antibody;LT-alpha antibody;Lta antibody;Lymphotoxin alpha (TNF superfamily, member 1) antibody;Lymphotoxin alpha antibody;Lymphotoxin-alpha antibody;MGC117668 antibody;OTTHUMP00000037612 antibody;OTTHUMP00000037613 antibody;TNF B antibody;TNF superfamily member 1 antibody;TNF, lymphocyte-derived antibody;TNF-beta antibody;TNFB antibody;TNFB_HUMAN antibody;TNFbeta antibody;TNFSF 1 antibody;TNFSF1 antibody;TNLG1E antibody;Tumor necrosis factor beta antibody;tumor necrosis factor ligand 1E antibody;Tumor necrosis factor ligand superfamily member 1 antibody;tumor necrosis factor superfamily member 1 antibody

SUBCELLULAR LOCATION

Membrane, Secreted

FUNCTION

Tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. Belonging to the hematopoietic cell line, LT-α exhibits anti-proliferative activity and causes the cellular destruction of tumor cell lines. As a cytotoxic protein, LT-α performs a variety of important roles in immune regulation depending on the form that it is secreted as. Unlike other members of the TNF superfamily, LT-α is only found as a soluble homotrimer, when found at the cell surface it is found only as a heterotrimer with LTβ. LT-α has a significant impact on the maintenance of the immune system including the development of secondary lymphoid organs. Absence of LT-α leads to the disruption of gastrointestinal development, prevents Peyer's patch development, and results in a disorganized spleen. As a signaling molecule, LT-α is involved in the regulation of cell survival, proliferation, differentiation, and apoptosis. LT-α plays an important role in innate immune regulation and its presence has been shown to prevent tumor growth and destroy cancerous cell lines. In contrast, unregulated expression of LT-α can result in a constantly active signaling pathway, thus leading to uncontrolled cellular growth and creation of tumors. Hence depending on the context, LT-α may function to prevent growth of cancer cells or facilitate the development of tumors. Furthermore, LT-α effects depend on the type of organ it acts upon, type of cancer cells, cellular environment, gender, and time of effect during an immune response.