Biotin Conjugated Human PDGF-BB Recombinant Rabbit Monoclonal Antibody [PSH05-99] (HA722585B)

UNIPROT #

P01127

PROTEIN NAME

Human PDGF-BB

SYNONYMS

Becaplermin antibody;c sis antibody;FLJ12858 antibody;Oncogene SIS antibody;PDGF 2 antibody;PDGF B chain antibody;PDGF Beta antibody;PDGF subunit B antibody;PDGF-2 antibody;PDGF2 antibody;Pdgfb antibody;PDGFB_HUMAN antibody;Platelet derived growth factor 2 antibody;Platelet derived growth factor B chain antibody;Platelet derived growth factor beta antibody;Platelet derived growth factor beta polypeptide (oncogene SIS) antibody;Platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog) antibody;Platelet derived growth factor beta polypeptide antibody;Platelet-derived growth factor B chain antibody;Platelet-derived growth factor beta polypeptide antibody;Platelet-derived growth factor subunit B antibody;Proto-oncogene c-Sis antibody;Simian sarcoma viral (v sis) oncogene homolog antibody;SIS antibody;SSV antibody;v sis platelet derived growth factor beta polypeptide antibody

SUBCELLULAR LOCATION

Secreted

FUNCTION

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.