Biotin Conjugated Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-81] (HA722652B)

UNIPROT #

P22301

PROTEIN NAME

Human IL-10

SYNONYMS

CSIF antibody;Cytokine synthesis inhibitory factor antibody;GVHDS antibody;IL 10 antibody;IL-10 antibody;IL10 antibody;IL10_HUMAN antibody;IL10A antibody;Interleukin 10 antibody;Interleukin-10 antibody;MGC126450 antibody;MGC126451 antibody;T-cell growth inhibitory factor antibody;TGIF antibody

SUBCELLULAR LOCATION

Secreted

FUNCTION

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively. IL-10 effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα, IL-1β, IL-12, and IFNγ secretion from Toll-Like Receptor (TLR) triggered myeloid lineage cells.