Biotin Conjugated Human CD85d Recombinant Rabbit Monoclonal Antibody [PSH05-62] (HA722592B)

UNIPROT #

Q8N423

PROTEIN NAME

Human CD85d

SYNONYMS

CD85 antigen-like family member D antibody;CD85d antibody;CD85d antigen antibody;ILT 4 antibody;ILT-4 antibody;ILT4 antibody;Immunoglobulin like transcript 4 antibody;Immunoglobulin-like transcript 4 antibody;Leukocyte immunoglobulin like receptor 2 antibody;Leukocyte immunoglobulin like receptor subfamily B member 2 antibody;Leukocyte immunoglobulin-like receptor 2 antibody;Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody;Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 antibody;LILRA6 antibody;LILRB2 antibody;LIR 2 antibody;LIR-2 antibody;LIR2 antibody;LIRb antibody;LIRB2_HUMAN antibody;MIR 10 antibody;MIR-10 antibody;MIR10 antibody;Monocyte/macrophage immunoglobulin like receptor 10 antibody;Monocyte/macrophage immunoglobulin-like receptor 10 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.