BIN1 Rabbit Polyclonal Antibody (ER1901-39)

UNIPROT #

O00499

PROTEIN NAME

BIN1

SYNONYMS

AMPH 2 antibody;AMPH2 antibody;Amphiphysin 2 antibody;Amphiphysin II antibody;Amphiphysin like protein antibody;amphiphysin-like antibody;Amphiphysin-like protein antibody;AMPHL antibody;Bin1 antibody;BIN1_HUMAN antibody;Box Dependant MYC Interacting Protein 1 antibody;Box-dependent myc-interacting protein 1 antibody;Bridging integrator 1 antibody;DKFZp547F068 antibody;MGC10367 antibody;MGC105358 antibody;Myc box dependent interacting protein 1 antibody;Myc box-dependent-interacting protein 1 antibody;SH3P9 antibody

TISSUE SPECIFICITY

Ubiquitous. Highest expression in the brain and muscle. Expressed in oligodendrocytes. Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by protein kinase C.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Endosome, Nucleus, Plasma membrane.

FUNCTION

Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.