Biglycan Recombinant Rabbit Monoclonal Antibody [JB71-31] (ET7107-48)

UNIPROT #

P21810

PROTEIN NAME

Biglycan

SYNONYMS

BGN antibody;Biglycan antibody;Biglycan proteoglycan antibody;Bone/cartilage proteoglycan I antibody;Dermatan sulphate proteoglycan I antibody;DSPG1 antibody;PG S1 antibody;PG-S1 antibody;PGI antibody;PGS1_HUMAN antibody;SEMDX antibody;SLRR1A antibody;Small leucine rich protein 1A antibody

SEQUENCE SIMILARITIES

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

TISSUE SPECIFICITY

Found in several connective tissues, especially in articular cartilages.

POST-TRANSLATIONAL MODIFICATION

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene[5] which is located on the X chromosome. Biglycan is believed to play a role in the mineralization of bone. Knock-out mice that have had the gene for biglycan suppressed (Bgn -/-) have an osteoporosis-like phenotype with reduced growth rate and lower bone mass than mice that can express biglycan. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity. It has also been reported that the presence of biglycan is necessary for BMP-4 to exert its effects on osteoblasts. There is also evidence that biglycan binds to TGF-beta 1.